PIPELINE OVERVIEW
Comparison of Measurable Parameters for Platform Tiers
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  • Electrophysiology
  • Action Potential
  • Ionic current composition
  • Calcium transient
  • Multicellular conduction
  • - Anisotropic electrical conduction
  • - Transmural gradients
  • - Cable-like conduction
  • Volume-conducted ECG
  • Contractility / Physiology
  • Cell shortening
  • Real-time force measurements
  • Pressure-Volume loop
  • Ejection fraction
  • Cardiac Output
  • Others
  • Single cell assays (e.g. Metabolic, Viability, Gene Expression, Immunostaining)
  • Human
    Ventricular
    Cardiomyocytes
    (hvCM)
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  • Cardiac
    Anisotropic
    Sheet
    (hvCAS)
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  • Cardiac
    Anisotropic
    Patch
    (hvCAP)
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  • Cardiac
    Tissue Strip
    (hvCTS)
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  • novoHeart™
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Comparison of Features for Platform Tiers
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  • Reprogramming for Personalization
  • Composition control
  • Custom-tailored cell alignment
  • Controllable microenvironments
  • Structure
  • Custom-designed automated bioreactor
  • Controllable active loading
  • Physiological, trabecula-like muscle
  • Active pump as a working heart
  • Human
    Ventricular
    Cardiomyocytes
    (hvCM)
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    • 2D
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  • Cardiac
    Anisotropic
    Sheet
    (hvCAS)
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    • 2D
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  • Cardiac
    Anisotropic
    Patch
    (hvCAP)
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    • 3D
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  • Cardiac
    Tissue Strip
    (hvCTS)
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    • 3D
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  • novoHeart™
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    • 3D
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